à 
Prix: Entrée libre
Auditorium (salle 1035)
5155, chemin de la rampe
Montréal (QC) Canada  H3T 2B2

Prof. Fiorenzo Vetrone, Université du Québec, Institut National de la Recherche Scientifique, Énergie, Matériaux et Télécommunications, 1650 Boul. Lionel-Boulet, Varennes, QC J3X 1S2 (CANADA).

Nanoparticles excited in the near-infrared (NIR) are quickly emerging as useful tools in diagnostic and therapeutic medicine. In particular, the usefulness of these nanomaterials for applications in biology stems primarily from the fact that NIR light is silent to tissues thus minimizing autofluorescence, possesses greater tissue penetration capabilities, reduced scattering, and does not cause photodamage to the specimen under investigation. Moreover, tailoring of the nanoparticles’ absorption and emission wavelengths allow them to operate within the so-called “biological windows”, regions of the spectrum in which tissues are partly transparent.

In this regard, lanthanide (Ln3+)-doped nanoparticles (LnNPs) are at the vanguard since they posses multiple absorption and emissions in these “biological windows” (approximately 750-1000, 1100-1450, and 1500-1700 nm). Thus, it is feasible to excite within one window and observe emission in another. Moreover, with LnNPs, it is possible to induce multiphoton excited luminescence (known as upconversion) where both the excitation (typically 980 nm) and emission lie within the “biological windows”. This multiphoton excitation process differs from what occurs in conventional multiphoton excited materials where the absorption of photons is simultaneous. In the case of LnNPs, the multitude of long-lived “real” electronic energy states of the Ln3+ ions (from the partially filled 4f shell) allow for sequential absorption of multiple NIR photons eliminating the need for complex and expensive optical excitation. Thus, upconverted luminescence can be observed using an inexpensive commercial continuous wave diode laser.         

Here, we present the synthesis and surface functionalization of various NIR excited nanoparticles and demonstrate how they can be used for biological applications. Furthermore, we show how they can be used as the cornerstone in the development of a multifunctional nanoplatform for the potential diagnostics and therapeutics of disease.

Site web du groupe du Prof. Vetrone

Cette conférence est présentée par le RQMP Versant Nord du Département de physique de l'Université de Montréal et le Département de génie physique de Polytechnique Montréal.

Near-Infrared Excited Nanoparticles: Synthesis and Applications – Prof. Fiorenzo Vetrone, INRS
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