Titre : Silicon Tether Motif in C-H Functionalization of Heterocycles and Beyond.
La conférence sera prononcée par le professeur Vladimir Gevorgyan du Département de chimie de l'University of Illinois at Chicago. Elle sera donnée en anglais.
Résumé : We have developed a set of new transition metal-catalyzed C-H activation methodologies employing a silicon-tether motif. These methods feature: (a) use of silyl group as a tether between a substrate and a reagent, thus transforming intermolecular reaction into intramolecular reaction; (b) employment of a silicon-tethered directing group, which is traceless or easily convertable into valuable functionalities; (c) use of silyl-tethered hydrosilane reagent; and (d) introduction of new N/Si-chelation concept that allows for a remote activation of aliphatic C-H bonds. The scope of these transformations will be demonstrated and the mechanisms will be discussed.
