A combination of the intact hippocampus preparation and optogenetics was used to investigate different aspects of theta rhtyhm network and dynamics. This work shows that parvalbumin-expressing basket interneurons play a key role in intrinsic hippocampal theta rhythm generation.
Conférencier :
Benedicte Amilhon, Ph.D., Postdoctoral Fellow, Department of Psychiatry, Douglas Mental Health University Institute, McGill University
Lectures suggérées :
Self-generated theta oscillations in the hippocampus. Romain Goutagny, Jesse Jackson & Sylvain Williams. Nature neuroscience VOLUME 12 | NUMBER 12 | december 2009, pp. 1491-1493.
Parvalbumin Interneurons of Hippocampus Tune Population Activity at Theta Frequency. Benedicte Amilhon, Carey Y.L. Huh, Frederic Manseau, Guillaume Ducharme, Heather Nichol, Antoine Adamantidis and Sylvain Williams. Neuron 86, 1277–1289, June 3, 2015 ª2015 Elsevier Inc. pp. 1277-1289.
Responsable : Louis-Éric Trudeau, professeur titulaire au Département de pharmacologie de la Faculté de médecine, Université de Montréal.
