Séminaire en épigénétique de l'UCEM
Sarah Kimmins, PhD, professeure agrégée, Biologie de la reproduction - Université McGill, titulaire de la Chaire de recherche du Canada de niveau II, Épigénétique, reproduction et développement.
«Experiencing infertility was hell. There’s just no other way to put it. We felt like failures—and worse, we couldn’t understand why»
Infertility is experienced by 17% of couples. It is a complicated and poorly understood health issue, attributable about 40% of the time to female factors, 40% to male factors and unexplained about 20% of the time. In the last two decades, sperm counts in men has halved; this is thought to be due in part to increased exposure to environmental chemicals and rising rates of obesity. We aim to better understand how the sperm epigenome functions in fertility and embryo development. We are currently running clinical trails to determine how fertility and BMI are related to the sperm epigenome and fertility. In the long-term we aim to use and sperm histone and DNA methylation signatures to predict fertility and clinical outcomes.