Titre : Chemical Tools for Selective Recognition of Posttranslational Modifications and Enzymes
Endroit: Pavillon Roger-Gaudry, Salle G-715
Hôte : Prof. Wiliam Lubell
Résumé : There can be no more noble undertaking than the invention of medicines. Chemists that make up the engine of drug discovery are facing incredible pressure to do more with less in a highly restrictive and regulated process that is destined for failure more than 95% of the time. How can academic chemists working on natural products help these heroes of drug discovery – those in the pharmaceutical industry? With selected examples from our lab, this talk will focus on that question highlighting interesting findings in fundamental chemistry and new approaches to scalable chemical synthesis.
Second, I will talk about the design and synthesis of molecular imaging agents for determining the role and subcellular distribution of lysine eraser enzymes such as lysine demethylases. We anticipate that these molecular imaging agents could lead to the discovery of novel protein biomarkers and new therapies for the treatment of diseases mediated by lysine demethylases.