Conférence de Chimie
Par le Professeur Evans P. Andrew
TITRE: Stereoselective Construction of Challenging C-C Bonds: Total Synthesis of Complex Bioactive Agents
RÉSUMÉ: The seminar will describe the development and application of new stereoselective C-C bond forming reactions to the total synthesis of complex bioactive agents. Specifically, it will outline a novel dynamic kinetic resolution of a,b-unsaturated aldehydes,[1] the catalytic asymmetric alkylation of homoenolates[2] and the development of a concise, efficient and scalable total synthesis of the complex bioactive sesquiterpene natural product, thapsigargin.[3]
References
- Majhi, J.; Turnbull, B. W. H.; Ryu, H.; Park, J.; Baik, M.-H.; Evans, P. A. J. Am Chem. Soc. 2019, 141, 11770.
- Wright, T. B.; Turnbull, B. W. H.; Evans, P. A. Angew. Chem. Int. Ed. 2019, 58, 9886.
- Chen, D.; Evans, P. A. J. Am. Chem. Soc. 2017, 139, 6046.
ID de réunion : 951 8306 3727
Code secret : 281020
